Nobel Prize in Physics for 2013
The Nobel Prize in Physics 2013 was awarded jointly to François Englert (left) and Peter W. Higgs (right) "for the theoretical discovery of a mechanism that contributes to our understanding of the origin of mass of subatomic particles, and which recently was confirmed through the discovery of the predicted fundamental particle, by the ATLAS and CMS experiments at CERN's Large Hadron Collider"
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François Englert and Peter W. Higgs are jointly awarded the Nobel Prize in Physics 2013 for the theory of how particles acquire mass. In 1964, they proposed the theory independently of each other (Englert together with his now deceased colleague Robert Brout). In 2012, their ideas were confirmed by the discovery of a so called Higgs particle at the CERN laboratory outside Geneva in Switzerland..
The awarded theory is a central part of the Standard Model of particle physics that describes how the world is constructed. According to the Standard Model, everything, from flowers and people to stars and planets, consists of just a few building blocks: matter particles. These particles are governed by forces mediated by force particles that make sure everything works as it should.
The entire Standard Model also rests on the existence of a special kind of particle: the Higgs particle. This particle originates from an invisible field that fills up all space. Even when the universe seems empty this field is there. Without it, we would not exist, because it is from contact with the field that particles acquire mass. The theory proposed by Englert and Higgs describes this process.
On 4 July 2012, at the CERN laboratory for particle physics, the theory was confirmed by the discovery of a Higgs particle. CERN’s particle collider, LHC (Large Hadron Collider), is probably the largest and the most complex machine ever constructed by humans. Two research groups of some 3,000 scientists each, ATLAS and CMS, managed to extract the Higgs particle from billions of particle collisions in the LHC.
Even though it is a great achievement to have found the Higgs particle — the missing piece in the Standard Model puzzle — the Standard Model is not the final piece in the cosmic puzzle. One of the reasons for this is that the Standard Model treats certain particles, neutrinos, as being virtually massless, whereas recent studies show that they actually do have mass. Another reason is that the model only describes visible matter, which only accounts for one fifth of all matter in the cosmos. To find the mysterious dark matter is one of the objectives as scientists continue the chase of unknown particles at CERN.
François Baron Englert was born in 1932 and is a Belgian theoretical physicist and 2013 Novel prize laureate (shared with Peter Higgs). He is Professor emeritus at the Universite libre de Bruxelles (ULB) where he is member of the Service de Physique Théorique. He is also a Sackler Professor by Special Appointment in the School of Physics and Astronomy at Tel Aviv University and a member of the Institute for Quantum Studies at Chapman University in California. He was awarded the 2010 J.J. Sakurai Prize for Theoretical Particle Physics (with Gerry Guralnik, C.R. Hagen, Tom Kibble, Peter Higgs and Robert Brout), the Wolf Prize in Physics in 2004 (with Brout and Higgs) and the High Energy and Particle Prize of the European Physical Society (with Brout and Higgs) in 1997 for the mechanism which unifies short and long range interactions by generating massive gauge vector bosons. He has made contributions in statistical physics, quantum field theory, cosmology, string theory and supergravity. He is the recipient of the 2013 Prince of Asturias Award in technical and scientific research, together with Peter Higgs and the CERN.
Peter W. Higgs CH, FRS, FRSE was born in 1929 and is a British theoretical physicist, Nobel laureate and emeritus professor at the University of Edinburgh. He is best known for his 1960s proposal of broken symmetry in electroweak theory, explaining the origin of mass of elementary particles in general and of the W and Z bosons in particular. This so-called Higgs mechanism, which was proposed by several physicists besides Higgs at about the same time, predicts the existence of a new particle, the Higgs boson (which was often described as "the most sought-after particle in modern physics". CERN announced on 4 July 2012 that they had experimentally established the existence of a Higgs-like boson, but further work is needed to analyse its properties and see if it has the properties expected from the Standard Model Higgs boson. On 14 March 2013, the newly discovered particle was tentatively confirmed to be + parity and zero spin, two fundamental criteria of a Higgs boson, making it the first known fundamental scalar particle to be discovered in nature (although previously, composite scalars such as the K had been observed over half a century prior). The Higgs mechanism is generally accepted as an important ingredient in the Standard Model of particle physics, without which certain particles would have no mass.
Nobel Prize in Chemistry for 2013
The Nobel Prize in Chemistry 2013 was awarded jointly to Martin Karplus (left), Michael Levitt (middle) and Arieh Warshel (right) "for the development of multiscale models for complex chemical systems".
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Chemists used to create models of molecules using plastic balls and sticks. Today, the modelling is carried out in computers. In the 1970s, Martin Karplus, Michael Levitt and Arieh Warshel laid the foundation for the powerful programs that are used to understand and predict chemical processes. Computer models mirroring real life have become crucial for most advances made in chemistry today.
Chemical reactions occur at lightning speed. In a fraction of a millisecond, electrons jump from one atomic to the other. Classical chemistry has a hard time keeping up; it is virtually impossible to experimentally map every little step in a chemical process. Aided by the methods now awarded with the Nobel Prize in Chemistry, scientists let computers unveil chemical processes, such as a catalyst’s purification of exhaust fumes or the photosynthesis in green leaves.
The work of Karplus, Levitt and Warshel is ground-breaking in that they managed to make Newton’s classical physics work side-by-side with the fundamentally different quantum physics. Previously, chemists had to choose to use either or. The strength of classical physics was that calculations were simple and could be used to model really large molecules. Its weakness, it offered no way to simulate chemical reactions. For that purpose, chemists instead had to use quantum physics. But such calculations required enormous computing power and could therefore only be carried out for small molecules.
This year’s Nobel Laureates in chemistry took the best from both worlds and devised methods that use both classical and quantum physics. For instance, in simulations of how a drug couples to its target protein in the body, the computer performs quantum theoretical calculations on those atoms in the target protein that interact with the drug. The rest of the large protein is simulated using less demanding classical physics.
Today the computer is just as important a tool for chemists as the test tube. Simulations are so realistic that they predict the outcome of traditional experiments.
Martin Karplus was born in 1930 and is an Austrian-born American theoretical chemist. He is the Theodore William Richards Professor of Chemistry, emeritus at Harvard University. He is also Director of the Biophysical Chemistry Laboratory, a joint laboratory between the French National Center for Scientific Research and the University of Strasbourg, France. Karplus received the 2013 Nobel Prize in Chemistry, together with Michael Levitt and Arieh Warshel, for "the development of multiscale models for complex chemical systems".
Michael Levitt, FRS was born in 1947 and is an American-British-Israeli biophysicist and a professor of structural biology at Stanford University, a position he has held since 1987. His research is in computational biology and he is a member of the National Academy of Sciences. Levitt received the 2013 Nobel Prize in Chemistry, together with Martin Karplus and Arieh Warshel, for "the development of multiscale models for complex chemical systems".
Arieh Warshel (Hebrew: אריה ורשל, was born in 1940 and is an Israeli-American Distinguished Professor of Chemistry and Biochemistry at the University of Southern California. He received the 2013 Nobel Prize in Chemistry, together with Michael Levitt and Martin Karplus for "the development of multiscale models for complex chemical systems".
Nobel Prize in Medicine for 2013
The Nobel Prize in Physiology or Medicine 2013 was awarded jointly to James E. Rothman (left), Randy W. Schekman (middle) and Thomas C. Südhof (right) "for their discoveries of machinery regulating vesicle traffic, a major transport system in our cells".
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The 2013 Nobel Prize was awarded jointly to three scientists who have solved the mystery of how the cell organizes its transport system. Each cell is a factory that produces and exports molecules. For instance, insulin is manufactured and released into the blood and signaling molecules called neurotransmitters are sent from one nerve cell to another. These molecules are transported around the cell in small packages called vesicles. The three Nobel Laureates have discovered the molecular principles that govern how this cargo is delivered to the right place at the right time in the cell.
Randy Schekman discovered a set of genes that were required for vesicle traffic. James Rothman unravelled protein machinery that allows vesicles to fuse with their targets to permit transfer of cargo. Thomas Südhof revealed how signals instruct vesicles to release their cargo with precision.
Through their discoveries, Rothman, Schekman and Südhof have revealed the exquisitely precise control system for the transport and delivery of cellular cargo. Disturbances in this system have deleterious effects and contribute to conditions such as neurological diseases, diabetes, and immunological disorders.
How cargo is transported in the cell
In a large and busy port, systems are required to ensure that the correct cargo is shipped to the correct destination at the right time. The cell, with its different compartments called organelles, faces a similar problem: cells produce molecules such as hormones, neurotransmitters, cytokines and enzymes that have to be delivered to other places inside the cell, or exported out of the cell, at exactly the right moment. Timing and location are everything. Miniature bubble-like vesicles, surrounded by membranes, shuttle the cargo between organelles or fuse with the outer membrane of the cell and release their cargo to the outside. This is of major importance, as it triggers nerve activation in the case of transmitter substances, or controls metabolism in the case of hormones. How do these vesicles know where and when to deliver their cargo?
Traffic congestion reveals genetic controllers
Randy Schekman was fascinated by how the cell organizes its transport system and in the 1970s decided to study its genetic basis by using yeast as a model system. In a genetic screen, he identified yeast cells with defective transport machinery, giving rise to a situation resembling a poorly planned public transport system. Vesicles piled up in certain parts of the cell. He found that the cause of this congestion was genetic and went on to identify the mutated genes. Schekman identified three classes of genes that control different facets of the cell´s transport system, thereby providing new insights into the tightly regulated machinery that mediates vesicle transport in the cell.
Docking with precision
James Rothman was also intrigued by the nature of the cell´s transport system. When studying vesicle transport in mammalian cells in the 1980s and 1990s, Rothman discovered that a protein complex enables vesicles to dock and fuse with their target membranes. In the fusion process, proteins on the vesicles and target membranes bind to each other like the two sides of a zipper. The fact that there are many such proteins and that they bind only in specific combinations ensures that cargo is delivered to a precise location. The same principle operates inside the cell and when a vesicle binds to the cell´s outer membrane to release its contents.
It turned out that some of the genes Schekman had discovered in yeast coded for proteins corresponding to those Rothman identified in mammals, revealing an ancient evolutionary origin of the transport system. Collectively, they mapped critical components of the cell´s transport machinery.
Timing is everything
Thomas Südhof was interested in how nerve cells communicate with one another in the brain. The signalling molecules, neurotransmitters, are released from vesicles that fuse with the outer membrane of nerve cells by using the machinery discovered by Rothman and Schekman. But these vesicles are only allowed to release their contents when the nerve cell signals to its neighbours. How is this release controlled in such a precise manner? Calcium ions were known to be involved in this process and in the 1990s, Südhof searched for calcium sensitive proteins in nerve cells. He identified molecular machinery that responds to an influx of calcium ions and directs neighbour proteins rapidly to bind vesicles to the outer membrane of the nerve cell. The zipper opens up and signal substances are released. Südhof´s discovery explained how temporal precision is achieved and how vesicles´ contents can be released on command.
Vesicle transport gives insight into disease processes
The three Nobel Laureates have discovered a fundamental process in cell physiology. These discoveries have had a major impact on our understanding of how cargo is delivered with timing and precision within and outside the cell. Vesicle transport and fusion operate, with the same general principles, in organisms as different as yeast and man. The system is critical for a variety of physiological processes in which vesicle fusion must be controlled, ranging from signalling in the brain to release of hormones and immune cytokines. Defective vesicle transport occurs in a variety of diseases including a number of neurological and immunological disorders, as well as in diabetes. Without this wonderfully precise organization, the cell would lapse into chaos.
James E. Rothman was born 1950 in Haverhill, Massachusetts, USA. He received his PhD from Harvard Medical School in 1976, was a postdoctoral fellow at Massachusetts Institute of Technology, and moved in 1978 to Stanford University in California, where he started his research on the vesicles of the cell. Rothman has also worked at Princeton University, Memorial Sloan-Kettering Cancer Institute and Columbia University. In 2008, he joined the faculty of Yale University in New Haven, Connecticut, USA, where he is currently Professor and Chairman in the Department of Cell Biology.
Randy W. Schekman was born 1948 in St Paul, Minnesota, USA, studied at the University of California in Los Angeles and at Stanford University, where he obtained his PhD in 1974 under the supervision of Arthur Kornberg (Nobel Prize 1959) and in the same department that Rothman joined a few years later. In 1976, Schekman joined the faculty of the University of California at Berkeley, where he is currently Professor in the Department of Molecular and Cell biology. Schekman is also an investigator of Howard Hughes Medical Institute.
Thomas C. Südhof was born in 1955 in Göttingen, Germany. He studied at the Georg-August-Universität in Göttingen, where he received an MD in 1982 and a Doctorate in neurochemistry the same year. In 1983, he moved to the University of Texas Southwestern Medical Center in Dallas, Texas, USA, as a postdoctoral fellow with Michael Brown and Joseph Goldstein (who shared the 1985 Nobel Prize in Physiology or Medicine). Südhof became an investigator of Howard Hughes Medical Institute in 1991 and was appointed Professor of Molecular and Cellular Physiology at Stanford University in 2008.
Nobel Prize in Literature for 2013
The Nobel Prize in Literature 2013 was awarded to Alice Munro "master of the contemporary short story".
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Alice Ann Munro (née Laidlaw); was born in 1931 and is a Canadian author writing in English. Munro's work has been described as having revolutionized the architecture of short stories, especially in its tendency to move forward and backward in time. Munro's fiction is most often set in her native Huron County in southwstern Ontario. Her stories explore human complexities in an uncomplicated prose style. Munro's writing has established her as "one of our greatest contemporary writers of fiction," or, as Cynthia Ozick put it, "our Chekhov." Alice Munro was awarded the 2013 Nobel Prize in Literature for her work as "master of the modern short story", and the 2009 Man Booker International Price for her lifetime body of work, she is also a three-time winner of Canada's Governor General's Award for fiction.
Nobel Prize in Economics for 2013
The Sveriges Riksbank Prize in Economic Sciences in Memory of Alfred Nobel 2013 was awarded jointly to Eugene F. Fama (left), Lars Peter Hansen (middle) and Robert J. Shiller (right) "for their empirical analysis of asset prices".
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There is no way to predict the price of stocks and bonds over the next few days or weeks. But it is quite possible to foresee the broad course of these prices over longer periods, such as the next three to five years. These findings, which might seem both surprising and contradictory, were made and analyzed by this year’s Laureates, Eugene Fama, Lars Peter Hansen and Robert Shiller.
Beginning in the 1960s, Eugene Fama and several collaborators demonstrated that stock prices are extremely difficult to predict in the short run, and that new information is very quickly incorporated into prices. These findings not only had a profound impact on subsequent research but also changed market practice. The emergence of so-called index funds in stock markets all over the world is a prominent example.
If prices are nearly impossible to predict over days or weeks, then shouldn’t they be even harder to predict over several years? The answer is no, as Robert Shiller discovered in the early 1980s. He found that stock prices fluctuate much more than corporate dividends, and that the ratio of prices to dividends tends to fall when it is high, and to increase when it is low. This pattern holds not only for stocks, but also for bonds and other assets.
One approach interprets these findings in terms of the response by rational investors to uncertainty in prices. High future returns are then viewed as compensation for holding risky assets during unusually risky times. Lars Peter Hansen developed a statistical method that is particularly well suited to testing rational theories of asset pricing. Using this method, Hansen and other researchers have found that modifications of these theories go a long way toward explaining asset prices.
Another approach focuses on departures from rational investor behavior. So-called behavioral finance takes into account institutional restrictions, such as borrowing limits, which prevent smart investors from trading against any mispricing in the market.
The Laureates have laid the foundation for the current understanding of asset prices. It relies in part on fluctuations in risk and risk attitudes, and in part on behavioral biases and market frictions.
Eugene Francis "Gene" Fama (/ˈfɑːmə/) was born in 1939 and is an American economist and Nobel laureate in Economics, known for his work on portfolio theory and asset pricing, both theoretical and empirical.
He is currently Robert R. McCormick Distinguished Service Professor of Finance at the University of Chicago Booth School of Business. In 2013 it was announced that he would be awarded the Nobel Prize in Economic Sciences jointly with Robert Shiller and Lars Peter Hansen.
Lars Peter Hansen was born in `1952 and is the David Rockefeller Distinguished Service Professor of economics at the University of Chicago. Best known for his work on the Generalize Method of Moments, he is also a distinguished macroeconomist, focusing on the linkages between the financial and real sectors of the economy. In 2013, it was announced that he would be awarded the Nobel Memorial Prize in Economics, jointly with Robert J. Shiller and Eugene Fama.
Robert James "Bob" Shiller was born in 1946 and is an American economist, academic, and best-selling author. He currently serves as a Sterling Professor of Economics at Yale University and is a fellow at the Yale School of Management's International Center for Finance. Shiller has been a research associate of the National Bureau of Economic Research (NBER) since 1980, was Vice President of the American Economic Association in 2005, and President of the Eastern Economic Association for 2006-2007. He is also the co‑founder and chief economist of the investment management firm MacroMarkets LLC. Shiller is ranked among the 100 most influential economists of the world. On 14 October 2013, it was announced that Shiller, together with Eugene Fama and Lars Peter Hansen, would receive the 2013 Nobel Prize in Economics, “for their empirical analysis of asset prices”.
Nobel Prize For Peace 2013
The Nobel Peace Prize 2013 was awarded to Organisation for the Prohibition of Chemical Weapons "for its extensive efforts to eliminate chemical weapons".
The Norwegian Nobel Committee has decided that the Nobel Peace Prize for 2013 is to be awarded to the Organisation for the Prohibition of Chemical Weapons (OPCW) for its extensive efforts to eliminate chemical weapons.
During World War One, chemical weapons were used to a considerable degree. The Geneva Convention of 1925 prohibited the use, but not the production or storage, of chemical weapons. During World War Two, chemical means were employed in Hitler’s mass exterminations. Chemical weapons have subsequently been put to use on numerous occasions by both states and terrorists. In 1992-93 a convention was drawn up prohibiting also the production and storage of such weapons. It came into force in 1997. Since then the OPCW has, through inspections, destruction and by other means, sought the implementation of the convention. 189 states have acceded to the convention to date.
The conventions and the work of the OPCW have defined the use of chemical weapons as a taboo under international law. Recent events in Syria, where chemical weapons have again been put to use, have underlined the need to enhance the efforts to do away with such weapons. Some states are still not members of the OPCW. Certain states have not observed the deadline, which was April 2012, for destroying their chemical weapons. This applies especially to the USA and Russia.
Disarmament figures prominently in Alfred Nobel’s will. The Norwegian Nobel Committee has through numerous prizes underlined the need to do away with nuclear weapons. By means of the present award to the OPCW, the Committee is seeking to contribute to the elimination of chemical weapons.
COMMENTARY: Congratulations to all recipients. The 2013 Nobel laureates include six Americans. Here's a YouTube video of the Nobel Prize Ceremony:
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